One of our biggest clients is the local psychiatric hospital because a good chunk of the facility is rehabilitation and addiction management. Lately, there’s been a population of patients who were coming up positive on the amphetamine drug screen but we have never been able to find anything that could explain it in the confirmations. This is not the most bizarre thing because amphetamines are very volatile so if you have a tiny concentration in the urine, you might lose it in the extraction (which contains dry down steps).
However! One day we got a box full of homemade cigarettes from the hospital which were taken from an “entrepreneur” who was selling them to patients and we were asked to do extractions on them to see if maybe we could find this mystery amphetamine or cross-reactant. (Unrelatedly, I thought the surgeon general’s warning sticker is a really charming touch)
We tried a number of extraction methods but never did find the amphet. In fact what surprised me was the fact that, compared to commercial cigarettes, these were actually really clean!